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Fig. 7 | Respiratory Research

Fig. 7

From: Classical monocyte-derived macrophages as therapeutic targets of umbilical cord mesenchymal stem cells: comparison of intratracheal and intravenous administration in a mouse model of pulmonary fibrosis

Fig. 7

Changes in macrophage subtype activation by MSCs in a murine fibrosis model. A The number of lung macrophages. B Dot plots showing lung AM and MoM distribution in vivo according to SiglecF versus CD11b marker expression. C, D Subtypes of SiglecF+ and SiglecF– lung macrophages according to CD11c and CD11b expression. E Changes in MoMs in the lungs and expression of CD86 and CD206 markers in MoMs (F) Changes in M2 macrophage subpopulations according to the expression of MHCII, CD206, and CD86 markers in the lungs. n = 5 for each group, *indicates P < 0.05, **indicates P < 0.01, ***indicates P < 0.001, ****indicates P < 0.0001. All results are representative of at least three independent experiments. MSC mesenchymal stem cell, AM alveolar macrophages, MoM monocyte-derived macrophage

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Respiratory Research

ISSN: 1465-993X

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