Lung Inflammation in alpha-1-antitrypsin deficient individuals with normal lung function

Respiratory Research

Table 1 Study Population Characteristics

Study	Deficient	Normal	p value
Age (years)	42 + 2	40 + 4	0.17
FEV₁ (% predicted)	101 + 3	107 + 4	0.058
FVC (% predicted)	103 + 6	104 + 4	0.43
TLC (% predicted)	105 + 4	104 + 4	0.82
DLco^a (% predicted)	112 + 4	103 + 5	0.22
\(\Delta\)FEV₁ (ml/year)	− 174 + 59	NA	NA
\(\alpha\)₁-AT Level (\(\upmu\)M)	5.2 + 0.2	27.7 + 1.0	< 0.0001^b

Values are expressed as mean and standard error of the mean (SE)
FEV₁, forced expiratory volume in one second; FVC, forced vital capacity; TLC, total lung capacity; DL_CO, diffusing capacity; \(\Delta\) FEV₁, rate of decline FEV₁/year
^aSingle breath (uncorrected)
^bSignificant correlation

ISSN: 1465-993X