Fig. 4
From: Responsiveness to pulmonary rehabilitation in COPD is associated with changes in microbiota
Responders and non-responders to dyspnoea, exercise capacity and impact of the disease present distinct patterns of longitudinal bacteria-inflammatory markers’ correlation. Correlation networks representing the repeated-measures correlations between bacteria and inflammatory markers in non-responders and responders to A dyspnoea (rmcorr: [− 0.75–0.52]) B exercise capacity (rmcorr: [− 0.73–0.66]) and C impact of the disease (rmcorr: [− 0.72–0.63]). Prior to the analysis, genera and ASVs: d0b698c7298bf04110a6d2f220879bfb and a5189f77a2cfeab3bc1602ff5c8ac3e9 relative frequencies were transformed with arcsine square root transformation and inflammatory markers’ concentration was transformed with log10. The diameter of the nodes is proportional to the number of connections. Bacterial nodes are coloured with the colour code of each bacterial phyla (Firmicutes: yellow, Bacteroidetes: blue; Proteobacteria: red; Fusobacteria: green Actinobacteria: pink; other phyla: grey). Inflammatory markers’ nodes are represented in beige. Positive correlations are represented in red, while negative correlations are represented in blue. The width of edges is proportional to the correlation coefficient