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Table 2 Multivariable MR for lung function on VTE (orientate to exposure FEV1)

From: Genetic association and causal inference between lung function and venous thromboembolism

Exposure

nSNPs

OR (95% CI)

Beta (SE)

P

Intercept (P)

Q_Pval (I2)

PRESSO (global P)

FEV1 vs. VTE

    

0.001 (0.477)

0.474 (0.002)

 < 0.001

 mvIVW

727

1.473 (0.516–4.202)

0.378 (0.535)

0.479

 mvMR-Egger

727

0.480 (0.051–4.506)

  

FVC vs. VTE

    

 mvIVW

727

0.492 (0.052–4.615)

− 0.709 (1.142)

0.535

 mvMR-Egger

727

1.857 (0.239–14.428)

  

FEV1/FVC vs. VTE

    

 mvIVW

727

1.885 (0.243–14.646)

0.634 (1.046)

0.544

 mvMR-Egger

727

1.449 (0.508–4.135)

  

PEF vs. VTE

    

 mvIVW

727

0.996 (0.843–1.177)

− 0.004 (0.085)

0.965

 mvMR-Egger

727

0.984 (0.830–1.167)

  

FEV1 vs. DVT

    

0.001 (0.499)

0.474 (0.002)

0.002

 mvIVW

726

1.613 (0.377–6.892)

0.478 (0.741)

0.519

 mvMR-Egger

726

0.393 (0.018–8.747)

  

FVC vs. DVT

    

 mvIVW

726

0.407 (0.018–9.067)

− 0.898 (1.583)

0.570

 mvMR-Egger

726

2.171 (0.126–37.299)

  

FEV1/FVC vs. DVT

    

 mvIVW

726

2.210 (0.129–37.902)

0.793 (1.450)

0.585

 mvMR-Egger

726

1.602 (0.375–6.844)

  

PEF vs. DVT

    

 mvIVW

726

1.006 (0.798–1.268)

0.006 (0.118)

0.959

 mvMR-Egger

726

0.990 (0.781–1.255)

  

FEV1 vs. PE

    

0.001 (0.703)

0.484 (0.001)

0.052

 mvIVW

727

1.694 (0.492–5.834)

0.527 (0.631)

0.404

 mvMR-Egger

727

0.374 (0.027–5.249)

  

FVC vs. PE

    

 mvIVW

727

0.378 (0.027–5.302)

− 0.974 (1.348)

0.470

 mvMR-Egger

727

2.361 (0.210–26.565)

  

FEV1/FVC vs. PE

    

 mvIVW

727

2.396 (0.213–27.020)

0.874 (1.236)

0.479

 mvMR-Egger

727

1.680 (0.488–5.788)

  

PEF vs. PE

    

 mvIVW

727

0.991 (0.799–1.229)

− 0.009 (0.110)

0.935

 mvMR-Egger

727

0.982 (0.790–1.221)

  
  1. FEV1 forced expiratory volume in one second; FVC forced vital capacity; FEV1/FVC the ratio of FEV1 to FVC; PEF peak expiratory flow; VTE venous thromboembolism; DVT deep vein thrombosis; PE pulmonary embolism; MR Mendelian randomization; SNP single nucleotide polymorphism; OR odds ratio; CI confidence interval; SE standard error; mvIVW multivariable inverse-variance weighted; PRESSO pleiotropy residual sum and outlier