Fig. 7
From: Intraluminal chloride regulates lung branching morphogenesis: involvement of PIEZO1/PIEZO2
Schematic representation of the role of intraluminal chloride concentrations in fetal branching morphogenesis. Increasing concentrations of intraluminal [Cl−] leads to increased branching morphogenesis and expression of neuroendocrine products, PIEZO channels, and smooth muscle markers. Pharmacological inhibition experiments show that these effects require PIEZO and Cl− channel activation. α-SMA, alpha-smooth muscle actin; CaCCinh calcium-dependent Cl− channel inhibitorA01; CFTRinh, cystic fibrosis transmembrane conductance regulator inhibitor172; MLC2, myosin light chain 2; SS, standard solution