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Table 2 Characteristics per GOLD stage

From: Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD

 

Never-smoked normal

GOLD 0

GOLD I

GOLD II

GOLD III

GOLD IV

N

67

2842

567

1483

892

451

Age (years)

59.5 [53.9–66.8]

55.6 [50.2–63.0]

61.9 [55.0–68.9]

62.6 [55.9–69.4]

65.2 [58.7–71.1]

64.4 [59.2–69.8]

Sex (%Males)

23 (34%)

1434 (50%)

323 (57%)

782 (53%)

522 (59%)

269 (60%)

Weight (kg)

81.0 [66.0–88.3]

82.7 [71.1–95.2]

77.6 [67.0–87.0]

82.0 [69.2–94.8]

80.0 [65.4–94.0]

72.2 [60.2–84.6]

Height (cm)

166.4 [159.8–173.4]

170.0 [163.0–177.0]

170.0 [162.6–177.8]

170.0 [162.9–176.6]

169.9 [162.6–177.0]

170.2 [163.0–176.6]

BMI (kg/m2)

27.5 [24.5–31.7]

28.3 [25.0–32.5]

26.5 [23.7–29.8]

27.9 [24.5–32.1]

27.1 [23.6–31.7]

24.8 [21.6–28.8]

Pack-years

0.0 [0.0–0.0]

34.2 [22.6–46.3]

40.8 [30.0–54.5]

45.5 [33.6–64.5]

49.5 [38.0–69.0]

49.5 [38.0–74.5]

FEV1 (L)

2.8 [2.3–3.4]

2.8 [2.4–3.3]

2.6 [2.2–3.1]

1.8 [1.5–2.2]

1.1 [0.9–1.3]

0.7 [0.5–0.8]

FEV1 (%Pred)

103.4 [93.8–115.6]

95.9 [88.5–104.4]

88.3 [84.2–95.2]

65.6 [57.7–72.0]

40.5 [35.4–45.0]

23.6 [19.0–26.7]

FVC (L)

3.6 [2.9–4.3]

3.6 [3.0–4.3]

4.1 [3.4–4.8]

3.1 [2.6–3.8]

2.6 [2.1–3.2]

2.1 [1.7–2.6]

FVC (%Pred)

98.5 [90.5–109.3]

95.5 [88.4–104.1]

105.3 [98.5–112.7]

85.2 [77.5–93.2]

70.7 [62.3–79.0]

55.5 [46.9–65.7]

FEV1/FVC

0.8 [0.8–0.8]

0.8 [0.7–0.8]

0.7 [0.6–0.7]

0.6 [0.5–0.7]

0.4 [0.4–0.5]

0.3 [0.3–0.4]

PEF (L/s)

7.8 [6.5–9.2]

7.4 [6.2–9.0]

6.9 [5.6–8.7]

5.2 [4.2–6.5]

3.4 [2.7–4.3]

2.3 [1.8–2.9]

FEF25-75 (L/s)

3.1 [2.3–3.6]

2.6 [2.0–3.3]

1.3 [0.9–1.6]

0.7 [0.5–1.0]

0.4 [0.3–0.4]

0.2 [0.2–0.3]

%Emphysema

0.2 [0.0–0.5]

0.2 [0.1–0.8]

1.5 [0.4–4.3]

2.7 [0.7–8.2]

13.6 [4.8–24.8]

27.0 [16.6–39.2]

%Gas Trapping

6.5 [4.3–10.0]

6.6 [3.1–11.2]

13.9 [8.0–21.5]

19.6 [11.8–28.5]

33.0 [25.0–39.5]

36.9 [31.7–43.5]

Pi10 (mm)

1.7 [1.5–1.9]

1.9 [1.7–2.2]

2.0 [1.8–2.4]

2.5 [2.2–2.9]

2.8 [2.5–3.2]

2.9 [2.5–3.2]

  1. Data are presented as median [Q1-Q3 interquartile range] and no. (%)
  2. BMI, body mass index; FEF25-75, mean forced expiratory flow between 25 and 75% of FVC; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; GOLD, Global Initiative for Chronic Obstructive Lung Diseases; PEF, peak expiratory flow; Pi10, internal perimeter of 10 mm