Table 5 Multivariate analysis

Gender, male

0.83

0.59–1.18

0.29

0.74

0.32–1.72

0.48

–

–

–

Age in years

1.00

0.98–1.02

0.9

–

–

–

1.04

1.01–1.07

0.011

Time of diagnosis by 5 year intervals

1.46

1.06–2.02

0.021

1.37

0.74–2.52

0.3

1.88

1.3–2.58

0.000

Radiological ILD pattern

 NSIP

1

–

–

–

–

–

–

–

–

 UIP

1.75

1.27–2.39

0.001

 Others

0.93

0.48–1.82

0.8

FVC% > 80

0.82

0.56–1.21

0.3

0.62

0.39–0.99

0.04

–

–

–

Glucocorticoids

0.94

0.62–1.41

0.7

1.07

0.59–1.93

0.8

0.53

0.34–0.83

0.006

Inmunomodulator therapy (csDMARDs; MTX, LEF, AZA, MMF, Tacro, AMs or biologic agents)

0.85

0.36–2.01

0.7

1.31

0.7–2.43

0.37

csDMARDs (MTX, LEF, AZA, MMF, Tacro, AMs)

1.13

0.75–1.71

0.5

Biologic agents: RTX

0.91

0.41–2.05

0.8

Ro antibodies + 

0.61

0.39–0.95

0.032

–

–

–

0.36

0.19–0.65

0.001

ANA antibodies + (≥ 1/320)

–

–

–

3.76

1.88–7.53

0.000

–

–

–