Table 2 Effects of almitrine bolus on clinical, oxygenation and echocardiographic variables in responders and non-responders
Non-responders (n = 16) | Responders (n = 46) | |||||
|---|---|---|---|---|---|---|
Before almitrine | After almitrine | p-value | Before almitrine | After almitrine | p-value | |
Clinical variables | ||||||
Respiratory rate (cycles/min) | 27 [22–32] | 28 [20–32] | 0.19 | 27 [22–30] | 28 [20–30] | 0.09 |
SpO2 (%) | 94 [91–94] | 95 [92–96] | 0.01 | 93 [90–95] | 98 [97–99]$ | < 0.01 |
Respiratory discomfort (mm) | 30 [20–50] | 30 [20–40] | 0.13 | 40 [20–50] | 30 [20–40] | 0.02 |
ROX index | 4.13 [3.43–4.75] | 3.60 [3.18–4.97] | 0.86 | 3.61 [3.26–4.34] | 4.00 [3.50–4.97] | < 0.01 |
Heart rate (bpm) | 85 [76–88] | 80 [72–87] | 0.39 | 79 [70–86] | 74 [66–83] | < 0.01 |
Systolic arterial pressure ( mmHg) | 134 [112–153] | 139 [127–150] | 0.91 | 129 [117–148] | 130 [120–148] | 0.42 |
Diastolic arterial pressure (mmHg) | 64 [55–71] | 61 [58–72] | 0.87 | 64 [53–72] | 65 [57–73] | 0.47 |
Mean arterial pressure (mmHg) | 90 [76–100] | 90 [83–96] | 0.78 | 86 [76–99] | 89 [79–98] | 0.68 |
Oxygenation variables | ||||||
FiO2 (%) | 90 [84–100] | 90 [89–100] | 0.33 | 100 [90–100] | 100 [86–100] | 0.32 |
PaO2 (mmHg) | 61 [57–68] | 68 [64–73] | < 0.01 | 65 [58–69] | 116 [99–159]$ | < 0.01 |
PaO2/FiO2 | 70 [62–75] | 76 [64–85] | < 0.01 | 67 [61–80] | 121 [102–162]$ | < 0.01 |
SaO2 (%) | 93 [92–94] | 95 [94–96] | < 0.01 | 94 [91–95] | 99 [98- 99]$ | < 0.01 |
PaCO2 (mmHg) | 33 [31–36] | 29 [27–33] | < 0.01 | 33 [31–37] | 32 [30–34] | < 0.01 |
Lactate (mmol/L) | 1.1 [0.9–1.6] | 1.4 [1.0–1.6] | 0.09 | 1.3 [1.0–1.4] | 1.2 [1.1–1.5] | 1.00 |
Echocardiographic variables | ||||||
RVEDA/LVEDA | 0.54 [0.50–0.55] | 0.56 [0.52–0.60] | < 0.01 | 0.54 [0.50–0.60] | 0.56 [0.51–0.60] | 0.03 |
TAPSE (mm) | 22 [18–26] | 22 [18–25] | 0.55 | 22 [20–25] | 21 [20–25] | 0.50 |
Tricuspid S wave (cm/s) | 14 [11–17] | 13 [11–15] | 0.25 | 14 [13–17] | 15 [13–16] | 0.67 |
VTI of the LV outflow tract ( cm) | 23 [23–26] | 22 [19–25] | 0.06 | 21 [18–23]* | 20 [17–25] | 0.14 |
Left ventricular ejection fraction (%) | 55 [48–59] | 55 [46–62] | 1.00 | 56 [47–60] | 56 [45–61] | 1.00 |