Gene network analysis for identification of microRNA biomarkers for asthma

Cay, Paulene; Singer, Cherie A.; Ba, Mariam A.

doi:10.1186/s12931-022-02304-2

Respiratory Research

Table 5 Correlation of 30 miRNA biomarker candidates with the features of asthma in HDM exposed mice

From: Gene network analysis for identification of microRNA biomarkers for asthma

miRNAs	Airway Resistance		Total Serum IgE		Inflammatory cell counts in BAL
miRNA ID	Spearman r	p-value	Spearman r	p-value	Spearman r	p-value
mmu-miRNA-135b-3p	0.584	0.0027	0.719	0.0002	0.814	< 0.0001
mmu-miRNA-147-5p	0.637	0.0008	0.848	1	0.779	< 0.0001
mmu-miRNA-3473b	0.529	0.0078	0.758	< 0.0001	0.662	< 0.0001
mmu-miRNA-148a-5p	0.552	0.0051	0.827	< 0.0001	0.701	< 0.0001
mmu-miRNA-7061-5p	0.436	0.0333	0.540	0.0095	0.561	0.0015
mmu-miRNA-146b-5p	0.504	0.0121	0.767	< 0.0001	0.829	< 0.0001
mmu-miRNA-217-5p	0.369	0.0756	0.392	0.0714	0.419	0.0236
mmu-miRNA-369-3p	0.508	0.0113	0.787	< 0.0001	0.614	0.0004
mmu-miRNA-204-5p	0.584	0.0027	0.732	0.0001	0.599	0.0006
mmu-miRNA-130b-5p	0.578	0.0031	0.720	0.0002	0.714	< 0.0001
mmu-miRNA-671-5p	0.434	0.0341	0.862	< 0.0001	0.627	0.0003
mmu-miRNA-340-5p	0.459	0.024	0.689	0.0004	0.641	0.0002
mmu-miRNA-9-3p	0.344	0.1003	0.792	< 0.0001	0.534	0.0029
mmu-miRNA-411-3p	0.463	0.0228	0.624	0.0019	0.376	0.0442
mmu-miRNA-296-5p	0.355	0.0889	0.607	0.0027	0.410	0.027
mmu-miRNA-503-5p	0.500	0.0128	0.900	< 0.0001	0.800	< 0.0001
mmu-miRNA-381-3p	0.416	0.0434	0.774	< 0.0001	0.610	0.0004
mmu-miRNA-125a-5p	− 0.433	0.0345	− 0.703	0.0003	− 0.638	0.0002
mmu-miRNA-193a-5p	− 0.252	0.2345	− 0.670	0.0006	− 0.525	0.0034
mmu-miRNA-24-3p	− 0.563	0.0042	− 0.682	0.0005	− 0.779	0.0001
mmu-miRNA-7224-3p	− 0.444	0.03	− 0.236	0.2915	− 0.540	0.0025
mmu-miRNA-491-5p	− 0.456	0.0252	− 0.658	0.0009	− 0.506	0.0051
mmu-miRNA-26a-5p	− 0.653	0.0005	− 0.618	0.0022	− 0.772	< 0.0001
mmu-miRNA-34c-3p	− 0.635	0.0009	− 0.475	0.0255	− 0.621	0.0003
mmu-miRNA-3097-5p	− 0.385	0.063	− 0.453	0.0341	− 0.472	0.0097
mmu-miRNA-6540-5p	− 0.512	0.0105	− 0.356	0.1036	− 0.366	0.0509
mmu-miRNA-195b	− 0.637	0.0008	− 0.689	0.0004	− 0.736	< 0.0001
mmu-miRNA-33-3p	− 0.503	0.0123	− 0.482	0.0232	− 0.422	0.0227
mmu-miRNA-1a-3p	− 0.471	0.0201	− 0.441	0.0399	− 0.585	0.0009
mmu-miRNA-1943-5p	− 0.518	0.0095	− 0.156	0.487	− 0.258	0.1772

The correlation coefficient, r, was calculated using Spearman's test, p < 0.05 was considered significant. BAL: bronchoalveolar lavage

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