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Fig. 5 | Respiratory Research

Fig. 5

From: Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs

Fig. 5

DSF inhibits the formation of N-GSDMD and the release of IL-18 and IL-1β in the lung tissue of hypoxia-induced PH rats. A Representative WB images and analysis of caspase-1 and CI. caspase-1. B Representative WB images and analysis of IL-18. C Representative WB images and analysis of IL-1β. D Representative WB images and analysis of GSDMD and N-GSDMD. E Representative WB images and analysis of NLRP3 and ASC. F, G ELISA detection of inflammatory factors (IL-18 and IL-1β). Values are the mean ± SEM. Statistical significance was analysed by one-way ANOVA followed by Bonferroni’s multiple comparison test or the Kruskal–Wallis test. *P < 0.05 vs. vehicle, and #P < 0.05 vs. normoxia (n = 5 each)

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Respiratory Research

ISSN: 1465-993X

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