Fig. 1

Patients with pulmonary hypertension (PH) have high expression levels of canonical caspase-1-dependent pyroptosis genes. A The gene expression levels of NLRP3, IL18 and CASP1 in the lung tissue of patients with PH (n = 15) and control subjects (n = 11). The database is GSE113439. B The gene expression levels of ASC and GSDMD in the lung tissue of patients with PH (n = 18) and control subjects (n = 13). The database is GSE15197. C An unnormalized UMAP plot of GSE113439 and GSE15197. D A normalized UMAP plot of the GSE113439 and GSE15197. E An unnormalized expression density plot of GSE113439 and GSE15197. F A normalization expression density plot for GSE113439 and GSE15197. G Normalized expression distribution plots for GSE113439 and GSE15197. H GSEA of the pyroptosis gene set. Normalized enrichment score (NES) = 1.5578, nominal P value = 0.0301. I Plasma IL-1β levels in patients with PH increase. J Plasma IL-18 levels in patients with PH increase. Values are the mean ± S.E.M. and were analysed by the unpaired two-tailed Student’s t test. *P < 0.05 vs. the normal control