Table 2 Lung function, blood analysis, health related quality of life and physical activity of patients with PI*ZZ genotype and comparison between augmented and non-augmented subjects
Variables | All ZZ (n = 629) | ZZ non-augmented (n = 436) | ZZ augmented (n = 190) | p value |
|---|---|---|---|---|
Lung function | ||||
FVC, % | 91.8 (23.7) | 96.1 (21.3) | 81.8 (26.1) | < 0.001 |
FEV1, % | 66.9 (30.7) | 76.3 (29.4) | 45.5 (21.7) | < 0.001 |
FEV1/FVC, % | 0.54 (0.2) | 0.59 (0.2) | 0.44 (0.1) | < 0.001 |
KCO, % | 68 (23.2) | 75.1 (22.4) | 55.8 (19.1) | < 0.001 |
Quality of life | ||||
CAT | 13.2 (9.3) | 12.5 (9.7) | 14.8 (8.4) | 0.001 |
BODEx | 2 (2.0) | 1.4 (1.8) | 3.3 (2.0) | < 0.001 |
EQ-5D | 0.82 (0.22) | 0.85 (0.20) | 0.73 (0.25) | < 0.001 |
VAS | 59.3 (28.2) | 62.9 (28.2) | 49.3 (25.7) | < 0.001 |
Exercise/activity | ||||
Active days in last week | 2.7 (2.4) | 2.7 (2.3) | 2.6 (2.4) | 0.717 |
Active days usual week | 2.8 (2.4) | 2.9 (2.4) | 2.7 (2.4) | 0.440 |
Minutes walked per day | 58.8 (63.9) | 59 (64.2) | 57.7 (63.0) | 0.924 |
Blood analysis | ||||
Haemoglobin | 14.8 (2.4) | 14.5 (2.6) | 15.3 (1.7) | 0.001 |
White blood cells | 7.0 (2.2) | 6.7 (2.0) | 7.6 (2.4) | < 0.001 |
Neutrophils | 4.5 (3.2) | 4.2 (2.5) | 5.1 (4.2) | 0.002 |
Eosinophils | 0.25 (0.60) | 0.22 (0.41) | 0.30 (0.85) | 0.121 |
Platelets | 237.8 (73.4) | 238.7 (70.9) | 237.0 (77.5) | 0.571 |
AAT (mg/dL)* | 23.8 (8.3) | 23.8 (8.7) | 23.8 (7.5) | 0.571 |
AST (UI/L) | 29.9 (17.4) | 30.8 (16.7) | 27.8 (13.1) | 0.202 |
ALT (UI/L) | 29.7 (17.9) | 30.1 (17.5) | 28.7 (19.0) | 0.474 |
GGT (UI/L) | 43.6 (44.1) | 41.5 (45.6) | 47.8 (40.8) | 0.001 |
FIB-4 | 1.6 (2.5) | 1.6 (2.1) | 1.8 (3.3) | 0.103 |