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Fig. 1 | Respiratory Research

Fig. 1

From: Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling

Fig. 1

The establishment and validation of COPD in rats and mice. A The timeline for constructing the model of COPD in rats. B The HE staining of the pulmonary in COPD-rats at week 12 and 18 compared to the control group, and between-groups differences in MLI. Scale bar, 50 µM. C The change in respiratory parmaters, including EF50, TV, PEF, PIF, and sRAW in normal rats, rats exposed to cigarette-smoking for 12 weeks, and rats exposed to cigarette-smoking for 18 weeks and elastase injection. D The timeline for constructing the model of COPD in mice. E The HE staining of the pulmonary in COPD mice at week 12 compared with the control group, and the between-group differences in MLI. Scale bar, 50 µM. F, G The pulmonary function change, including RI/Cdyn (F), PEF PIF, TV, and MV (G), in normal and COPD mice at 12 week

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Respiratory Research

ISSN: 1465-993X

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