Fig. 4
From: New variants of alpha-1-antitrypsin: structural simulations and clinical expression
Surface representation of the wild-type (WT) human AAT and mutants V210E, N247S, Pi*S + Asp341His and Pi*S + Leu383Phe + Lys394Ile molecular structures (a and e). Molecular solvent accessible surfaces are colored by the electrostatic potential calculated using the APBS program with nonlinear Poisson-Boltzmann equation and contoured at ± 5 kT/e (negatively and positively charged surface areas in red and blue, respectively). Black arrows indicate the location of the substitutions in each mutant