Fig. 2
From: New variants of alpha-1-antitrypsin: structural simulations and clinical expression
Structural mapping and analysis of the AAT variants identified. The central image is a cartoon representation of the molecular coordinates of human AAT1, with the serpin RCL shown in black, alpha-helices in red and beta-sheet regions A, B and C in yellow, cyan, and green, respectively. Mutated residues are highlighted in vdW surface (light violet = new variants; deep purple = Pi*Z and Pi*S). Structural comparisons by superposition of the AAT wild type and mutant molecular coordinates appear highlighted in the square insets (a to f). In d, reference (GlcNAc)2 glycan from (PDBid: 7API) is displayed in sticks. Residues (in sticks) are numbered according to the processed mature form of the protein