Fig. 2

ESWT, CWRCE and 6MWT; Mean change from baseline, LAMA/LABA vs placebo and LAMA/LABA vs monotherapy. Fixed effects analysis model. Aclid aclidinium, CI confidence interval, CWRCE constant work rate cycle ergometry, EET exercise endurance time, ESWT endurance shuttle walk test, Formo formoterol, IV inverse variance, LABA long-acting beta-2 agonists, LAMA long-acting muscarinic antagonists, Olo olodaterol, Plcb placebo, SE standard error, Std. standardized, Tio Tiotropium, Ume umeclidinium, Vila vilanterol, 6MWT 6-min walking test, µm microgram