Fig. 5

ADAM9 abundance in pulmonary arteries. A Representative images of ADAM9 (Red) endothelial cell marker CD31 (green), and DAPI (blue) abundance detected by immunofluorescence performed on human lung tissue from non-smokers and smokers without COPD, GOLD stage 4 COPD, and COPD-PH individuals. White arrows point to pulmonary arteries. Images were captured at 20X; scale bar is 50 µm. B, C Quantification of ADAM9 abundance in (B) small pulmonary arteries and (C) the microvasculature. For all graphs, each data point represents an individual; n = number of individuals in each group; horizontal lines are mean ± SEM; 1-way ANOVA with Dunnett’s multiple comparisons test was used for statistical analysis