Table 2 Associations of airway and systemic inflammation by symptoms of anxiety, depression and combined anxiety and depression compared to severe asthma with no anxiety and/or depression
|  | Severe asthma with Anxiety (Severe asthma + A) compared to Severe asthma with No Anxiety and/or Depression (severe asthma no A and/or D) | Severe asthma with Depression (Severe asthma + D) compared to Severe asthma with No Anxiety and/or Depression (severe asthma no A and/or D) | Severe asthma with both Anxiety and Depression (Severe asthma + A & D) compared to Severe asthma with No Anxiety and/or Depression (severe asthma no A and/or D) | ||||||
|---|---|---|---|---|---|---|---|---|---|
Yes | No | p-value | Yes | No | p-value | Yes | No | p-value | |
Airway | |||||||||
 Sputum Eosinophil | |||||||||
  Low < 3% | 5 (55.6) | 29 (46.8) | 0.62 | 14 (46.7) | 29 (46.8) | 0.99 | 6 (40.0) | 29 (46.8) | 0.64 |
  High > 3% | 4 (44.4) | 33 (53.3) | 16 (53.3) | 33 (53.2) | 9 (60.0) | 33 (52.2) | |||
 Sputum Neutrophil | |||||||||
  Low < 60% | 6 (66.7) | 45 (72.6) | 0.71 | 22 (73.3) | 45 (72.6) | 0.94 | 13 (86.7) | 45 (72.6) | 0.26 |
  High > 60% | 3 (33.3) | 17 (27.4) | 8 (26.7) | 17 (27.4) | 2 (13.3) | 17 (27.4) | |||
Systemic | |||||||||
 hs-CRP | |||||||||
  Low < 3 mg/L | 3 (30.0) | 48 (69.6) | 0.02 | 12 (32.4) | 48 (69.6) | < 0.001 | 7 (41.2) | 48 (69.6) | 0.03 |
  High > 3 mg/L | 7 (70.0) | 21 (30.4) | 25 (67.6) | 21 (30.4) | 10 (58.8) | 21(30.43) | |||