Table 2 Cell density per layer (intraepithelial: IE, submucosal: SM, and airway smooth muscle: ASM) in bronchial biopsies of patients with severe therapy-resistant asthma (STRA) (n = 6 to 11)

Tissue area (mm²)

11

1.62

1.24–2.39

Thickness MB (µm)

10

7.66

6.74–8.30

Length (µm)

10

10,217

8535–14,664

IE (cell/mm BM)

 Eosinophils

11

3.94

1.38–14.03

 Neutrophils

9

1.24

0.98–1.66

 Tryptase

9

4.71

0.66–20.23

 Chymase

9

1.85

1.70–3.49

 CD4 T cells

9

6.73

2.87–10.29

 CD8 T cells

8

55.91

44.34–72.32*

SM (cell/mm BM)

 Eosinophils

11

9.68

2.63–18.00

 Neutrophils

11

4.46

1.27–12.65

 Tryptase

10

17.99

13.38–27.81

 Chymase

10

9.72

3.67–16.88

 CD4 T cells

10

7.03

1.64–7.65

 CD8 T cells

10

31.56

24.04–34.60**

ASM (cell/mm² area)

 Eosinophils

6

7.92

7.13–18.05

 Neutrophils

7

4.03

0.21–6.01

 Tryptase

8

135.74

65.56–230.53^#

 Chymase

7

71.45

52.20–103.32

 CD4 T cells

6

59.01

5.98–79.43

 CD8 T cells

7

51.47

19.32–133.39