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Table 4 Cluster analysis behavior variables included

From: Stratification of COPD patients towards personalized medicine: reproduction and formation of clusters

Cluster

1

2

3

4

Number

22

26

24

26

Variables used in clustering*

  

Age in years

57 [50–71]**

62 [57–68]

65 [60.5–73]

63 [53–68]

Smoked PY

39 [26–57]

32 [20–40]

33 [19–55]

39 [23–50]

FEV1% pred

71 [54–84]

56 [42–66]

71 [60–80]

44 [36–53]

Dynamic hyperinflation post [air trapping]

− 0.22 [− 0.31–0.06]

− 0.31 [− 0.41–0.22]

− 0.12 [− 0.27 to − 0.04]

− 0.3 [− 0.43 to − 0.17]

BMI kg/m2

25 [23–29]

25 [21–28]

33 [30–36]

22 [19–29]

MMRC dyspnoea score

2 [1–3]

1 [0–1]

1 [1–2]

2 [1–3]

CCQ total score

2.8 [2.6–3.6]

0.9 [0.6–1.7]

2.4 [1.5–2.8]

2.3 [1.8–2.8]

BDI-PC total score

6 [4–10]

0.5 [0–1]

1 [0.5–1.5]

1 [1–3]

Exacerbations p/y

2 [1–3]

0.5 [0–1]

1 [0.5–1.5]

1 [1–3]

Steps per day

3885 [2442–5147]

7010 [5063–9343]

3727.5 [2781–5066]

5361 [3516–7221]

NCSI quality of life

42.1 [32.1–55.6]

7.4 [4.4–10.4]

11.5 [6.7–17.9]

19.6 [11–29.7]

NCSI satisfaction relationship

6 [5–8]

2 [2–3]

2 [2–3]

2 [2–4]

NCSI activities of daily living

20.3 [8.8–36.9]

5.4 [0–12.7]

17.6 [10.5–23.5]

20.9 [12.3–26.0]

NCSI fatigue

49.5 [44–53]

32 [27–38]

41 [33.5–47]

41 [37–49]

Other patient and disease characteristics

  

Male/ female %

55/45

38/62

67/33

46/54

FVC% pred

0.895 [0.83–1.05]

1.03 [0.87–1.11]

0.9 [0.84–1.01]

0.96 [0.76–1.04]

GOLD stage %

    

 1

27

0

25

7

 2

59

62

67

31

 3

9

38

8

46

 4

4

0

0

15

BOD score

2 [1–5]

2 [1–3]

2 [1–3]

4 [3–5]

  1. *Hierarchical clustering is performed based 5 components with an eigenvalue > 1 with variables: age, packyears, FEV1% pred, BMI, mMRC, CCQ, BDI-PC, number of exacerbations per year, steps per day, QoL, satisfaction relationship, activities of daily living, fatigue, and dynamic hyperinflation
  2. **Data are presented as N (%) or median [25–75 interquartile], unless otherwise stated. PY packyears, FEV1% pred Forced Expiratory Volume in 1 s percentage predicted, FVC Forced Vital Capacity, BMI Body Mass Index, MMRC Modified Medical Research Council, CCQ Clinical COPD Questionnaire, BDI-PC Beck Depression Inventory for primary care. BOD Body mass index, airflow Obstruction and Dyspnea score