Table 3 Cluster analysis reproducing four clinical phenotypes

Number

37

14

32

39

Variables used in clustering*

Age in years

64 [57–71]**

55 [48–61]

65 [58–71.5]

63 [57–68]

Smoked PY

40 [25–53]

50 [30–66]

22 [5–35]

42 [30–57]

FEV1% pred

39 [30–52]

56 [51–79]

68 [62–80]

59 [49–72]

BMI kg/m²

21 [19–25]

26 [21–35]

28 [25–31]

29 [24–35]

mMRC dyspnoea score

2 [1–3]

3.5 [1–4]

1 [0.5–1.5]

1 [0–1]

CCQ total score

2.5 [2–3.2]

3.3 [2.8–4.3]

1.9 [1.3–2.7]

1.2 [0.7–2.4]

BDI-PC total score

1 [1–4]

9.5 [7–11]

1 [0–2.5]

1 [0–2]

Exacerbations p/y

1 [1–3]

1 [1–3]

2 [1–3]

0 [0–1]

Other patient and disease characteristics

Male/female %

46/54

71/29

47/53

59/41

FVC% pred

87 [72–101]

89 [77–105]

99 [91–115]

93 [75–108]

GOLD stage %

 1

0

21

25

10

 2

35

64

66

64

 3

46

7

9

26

 4

19

7

0

0

BOD score

4 [4–5]

5 [1–5]

2 [1–2]

2 [1–3]

Steps per day

5283 [3165–7116]

3032 [2277–3936]

5037 3416–6797]

5041 [3371–8371]

NCSI quality of life

19 [11–31]

57 [41–63]

14 [6–24]

12 [6–23]

NCSI satisfaction relationship

3 [2–5]

6 [4–7]

2 [2–3]

3 [2–4]

NCSI activities of daily living

22 [12–30]

18 [9–28]

17 [5–29]

12 [3–18]

NCSI shortness of breath

12 [10–17]

16 [12–20]

10 [8–15]

10 [7–13]

NCSI fatigue

42 [37–47]

49 [38–55]

39 [32–50]

38 [29–45]

Main corresponding ABCD groups

 A

8 (21)

3 (21)

6 (19)

30 (77)

 B

11 (30)

5 (36)

5 (16)

9 (23)

 C

7 (19)

1 (7)

18 (56)

0 (0)

 D

11 (30)

5 (36)

3 (9)

0 (0)