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Table 2 Cluster analysis (ABCD groups) using the variables exacerbation number and mMRC

From: Stratification of COPD patients towards personalized medicine: reproduction and formation of clusters

Cluster

Group A

Group B

Group C

Group D

Number

61

37

31

26

Cluster number

    

1

0*

0

24 (65)

13 (35)

2

0

9 (41)

0

13 (59)

3

14 (33)

28 (67)

0

0

4

47 (87)

0

7 (13)

0

Variables used in clustering**

Exacerbations p/y

0 [0–1]

1 [0–1]

2 [2–3]

3 [3–3]

mMRC dyspnoea score

1 [0–1]

2 [2–3]

1 [0–1]

3 [2–4]

Other patient and disease characteristics

Male/ female %

53/47

62/38

45/55

42/58

Age in years

62 [54–68]

66 [60–71]

62 [55–67]

61 [52–70]

Smoked PY

40 [21–50]

40 [25–63]

28 [19–50]

33 [26–55]

FEV1% pred

62 [48–73]

52 [43–65]

63 [43–69]

54 [30–70]

GOLD stage %

    

 1

15

11

23

12

 2

59

50

52

44

 3

26

33

22

20

 4

0

6

3

24

BMI kg/m2

26 [21–30]

31 [22–36]

27 [24–29]

24 [20–30]

CCQ total score

1.4 [0.8–2.5]

2.7 [1.9–3.3]

2.1 [1.6–2.7]

3.2 [2.7–3.9]

CAT

13 [9–18]

21 [16–24]

18 [13–23]

27 [21–28]

BDI-PC total score

1 [1–2]

1 [1–4]

1 [0–4]

3 [2–6]

BOD score

1 [1–3]

4 [3–5]

2 [1–3]

5 [4–7]

Steps per day

5261 [3863–8260]

4042 [2466–5733]

5743 [4473–6904]

3936 [2226–5777]

NCSI quality of life

13 [7–21]

20 [11–28]

14 [6–28]

32 [22–42]

NCSI satisfaction relationship

3 [2–4]

3 [2–5]

2 [2–4]

5 [3–6]

NCSI activities of daily living

8 [3–17]

22 [14–27]

12 [5–24]

28 [13–40]

NCSI fatigue

35 [28–41]

42 [38–48]

43 [35–49]

44 [38–51]

  1. *Data are presented as N (%) or median [25–75 interquartile], unless otherwise stated. PY packyears, FEV1% pred forced expiratory volume in 1 s percentage predicted, BMI Body Mass Index, mMRC Modified Medical Research Council, CCQ Clinical COPD Questionnaire, BDI-PC Beck Depression Inventory for primary care. *Definition of group A: mMRC < 2 and exacerbations < 2, group B: mMRC >  = 2 and exacerbations < 2, group C: mMRC < 2 and exacerbations >  = 2, group D: mMRC >  = 2 and exacerbations >  = 2
  2. **Hierarchical clustering is performed based on two variables: Exacerbation per/year and mMRC