Fig. 3

Overview of cluster analysis replicating Burgel. In the first column Burgel’s four clinical phenotypes are shown, and in the second column our four reproduction clusters are visualized. Burgel used Hospital Anxiety and Depression (HAD) scale as depression scale whereas the reproduction cluster used the Beck Depression Inventory-Primary Care (BDI-PC) scale. Burgel used St. George’s Respiratory Questionnaire (SGRQ) to measure quality of life (QOL) and the reproduction cluster used CCQ. To improve optical comparison between the two cohorts, the BDI-PC median [IQR] of the replication clusters are re-calculated in the range of the HAD scale and the CCQ median [IQR] re-calculated in the range of the SGRQ. Re-calculation is outlined in the Methods section