Abnormal pulmonary hemodynamics during exercise is associated with exercise capacity in COPD

Respiratory Research

Table 3 Correlation of exercise capacity with pulmonary hemodynamics, right ventricular function and pressure/cardiac output slopes of all subjects

Value	Peak oxygen uptake (% predicted)		6 min walk distance (m)
Value	Spearman correlation	p-value	Spearman correlation	p-value
Resting meanPAP, mmHg	− 0.461	p = 0.007	− 0.145	p = 0.338
Resting PAWP, mmHg	− 0.126	p = 0.485	0.071	p = 0.639
Resting RAP, mmHg	0.042	p = 0.817	0.015	p = 0.920
Resting CI, L/min/m²	− 0.222	p = 0.241	− 0.105	p = 0.487
Resting TPR, WU	− 0.389	p = 0.025	− 0.249	p = 0.095
Resting PVR, WU	− 0.318	p = 0.072	− 0.239	p = 0.109
Peak meanPAP, mmHg	− 0.445	p = 0.009	− 0.019	p = 0.901
Peak PAWP, mmHg	0.052	p = 0.776	− 0.204	p = 0.184
Peak RAP, mmHg	− 0.264	p = 0.138	0.116	p = 0.441
Peak CI, L/min/m²	0.337	p = 0.055	0.542	p < 0.001
Peak TPR, WU	− 0.422	p = 0.016	− 0.432	p = 0.003
Peak PVR, WU	− 0.517	p = 0.003	− 0.155	p = 0.333
Peak PVC, mL/mmHg	0.490	p = 0.004	0.301	p = 0.047
Peak PA stiffness index, mmHg/m²/mL	− 0.562	p = 0.001	− 0.260	p = 0.089
RVOR, L/min/m²	0.492	p = 0.004	0.577	p < 0.001
mPAP/CO slope, mmHg/L/min	− 0.459	p = 0.007	− 0.464	p = 0.001
PAWP/CO slope, mmHg/L/min	− 0.189	p = 0.293	− 0.547	p < 0.001
RAP/CO slope, mmHg/L/min	− 0.331	p = 0.064	− 0.215	p = 0.155
TPG/CO slope, mmHg/L/min	− 0.423	p = 0.014	− 0.173	p = 0.250

mPAP mean pulmonary artery pressure, PAWP pulmonary artery wedge pressure, RAP right atrial pressure, PVR pulmonary vascular resistance, CO cardiac output, PVC pulmonary vascular compliance, PA stiffness pulmonary artery stiffness, RVOR right ventricular output reserve, TPG transpulmonary gradient

ISSN: 1465-993X