Table 2 Pulmonary hemodynamics and right ventricular function at rest and during exercise
From: Abnormal pulmonary hemodynamics during exercise is associated with exercise capacity in COPD
Variable | COPD N = 26 | Controls N = 26 | p-value |
|---|---|---|---|
RHC at rest | |||
mPAP, mmHg | 21 (18–23) | 17 (14–20) | p = 0.022 |
PAWP, mmHg | 8 (6–10) | 8 (6–10) | p = 0.789 |
RAP, mmHg | 5 (3–6) | 5 (4–6) | p = 0.492 |
PVR, WU | 2.5 (1.9–3.0) | 1.9 (1.5–2.4) | p = 0.020 |
TPR, WU | 4.3 (3.8–5.7) | 3.5 (2.7–4.4) | p = 0.007 |
CO, L/min | 4.4 (3.8–5.8) | 4.5 (4.0–5.3) | p = 0.742 |
CI, L/min/m2 | 2.6 (2.3–3.1) | 2.6 (2.3–2.8) | p = 0.782 |
PVC, mL/mmHg | 3.7 (2.7–5.0) | 4.0 (3.0–5.1) | p = 0.351 |
PA stiffness index, mmHg/m2/mL | 0.50 (0.37–0.62) | 0.45 (0.35–0.59) | p = 0.498 |
RHC at 25 Watt | |||
mPAP, mmHg | 36 (30–41) | 29 (21–35) | p = 0.025 |
PAWP, mmHg | 13 (11–23) | 13 (11–17) | p = 0.302 |
RAP, mmHg | 8 (6–13) | 7 (4–11) | p = 0.271 |
PVR, WU | 3.0 (1.9–4.0) | 2.2 (1.2–2.6) | p = 0.110 |
TPR, WU | 5.2 (4.1–7.3) | 3.9 (3.1–5.1) | p = 0.024 |
CO, L/min | 6.6 (5.3–8.5) | 7.0 (5.8–8.4) | p = 0.323 |
CI, L/min/m2 | 3.7 (3.2–4.7) | 3.8 (3.4–4.6) | p = 0.534 |
PVC, mL/mmHg | 4.3 (2.4–5.5) | 3.6 (2.5–6.2) | p = 0.607 |
PA stiffness index, mmHg/m2/mL | 0.49 (0.32–0.82) | 0.50 (0.41–0.77) | p = 0.442 |
RHC at 50 Watt | |||
mPAP, mmHg | 46 (39–51) | 31 (24–41) | p = 0.006 |
PAWP, mmHg | 19 (12–26) | 16 (12–21) | p = 0.203 |
RAP, mmHg | 12 (9–17) | 9 (5–13) | p = 0.068 |
PVR, WU | 2.8 (1.9–3.5) | 1.8 (1.1–2.5) | p = 0.053 |
TPR, WU | 5.4 (4.2–6.6) | 3.7 (2.7–4.8) | p = 0.013 |
CO, L/min | 8.1 (7.1–9.7) | 8.6 (7.8–10.0) | p = 0.273 |
CI, L/min/m2 | 4.6 (4.3–5.5) | 4.9 (4.4–5.3) | p = 0.396 |
PVC, mL/mmHg | 2.0 (1.7–2.5) | 3.6 (2.4–4.5) | p = 0.010 |
PA stiffness index, mmHg/m2/mL | 0.84 (0.72–1.05) | 0.53 (0.41–0.77) | p = 0.023 |
RHC at individual peak exercise | |||
Maximal exercise level, Watt | 50 (50–75) | 100 (75–125) | p = 0.002 |
Peak VO2, %predicted | 64 (55–82) | 95 (87–102) | p < 0.001 |
mPAP, mmHg | 47 (40–52) | 38 (32–44) | p = 0.015 |
PAWP, mmHg | 20 (15–28) | 20 (15–25) | p = 0.495 |
RAP, mmHg | 14 (8–18) | 11 (7–14) | p = 0.165 |
PVR, WU | 3.1 (2.2–3.7) | 1.7 (1.1–2.9) | p = 0.028 |
TPR, WU | 5.7 (4.5–7-0) | 3.8 (2.6–5.2) | p = 0.005 |
CO, L/min | 7.8 (7.0–10.9) | 10.3 (8.1–13.5) | p = 0.044 |
CI, L/min/m2 | 4.7 (4.2–5.7) | 6.2 (4.5–7.9) | p = 0.034 |
PVC, mL/mmHg | 1.9 (1.6–2.6) | 3.0 (2.0–4.4) | p = 0.045 |
PA stiffness index, mmHg/m2/mL | 0.84 (0.70–1.11) | 0.61 (0.42–1.00) | p = 0.056 |
RVOR (CIexercise-rest/CIrest) | 0.9 (0.5–1.2) | 1.3 (0.7–1.8) | p = 0.020 |
Slopes | |||
mPAP/CO slope, mmHg/L/min | 6.9 (5.0–10.9) | 3.7 (2.4–7.4) | p = 0.007 |
PAWP/CO slope, mmHg/L/min | 2.9 (1.9–6.4) | 1.8 (1.3–4.2) | p = 0.051 |
RAP/CO slope, mmHg/L/min | 2.3 (1.3–4.2) | 1.2 (0.5–2.1) | p = 0.025 |
TPG/CO slope, mmHg/L/min | 3.5 (1.6–4.5) | 1.6 (0.9–3.5) | p = 0.048 |