Fig. 4

Development of a prognostic signature with the UBE2T-related cell cycle genes. A Weighted Gene Correlation Network Analysis (WGCNA) clustering of Samples. B The optimal soft-threshold (power) is estimated with the scale-free fit index. C The Mean connectivity for various soft thresholding powers. D Heatmap of the correlation between the module eigengenes and clinical traits of LUAD. We selected the MEturquoise-grade block for subsequent analysis. E The receiving operator characteristic (ROC) curves of 1, 3, and 5 years of the optimized 8-gene signature derived from LASSO regression analysis. F Forest plot shows the univariate Cox regression analysis of OS for the essential genes included in the prognostic signature. G Correlation between the expression levels of eight key genes and infiltration of CD + 4 T cells, dendritic cells, and CD + 8 T cells in LUAD tumors (TIMER2.0) (http://timer.comp-genomics.org/)