Fig. 2
From: PKD1 deficiency induces Bronchiectasis in a porcine ADPKD model
PKD1deficiency promoted inflammation and mucus retention in pig lungs. (A) H&E staining of 2-year-old Control and PKD1+/− pig airways and quantification of airways with mucus in 2-year-old pigs. n = 3. Scale bar: 100 μm. (B) Immunofluorescence staining of CCL2 in 2 years old pig lungs. Scale bar: 100 μm. (C) Real-time PCR analysis of inflammation related genes in 2-year-old Control and PKD1+/− pig lungs. n = 3. (D) PAS staining of 2-years-old pig lungs. Scale bar: 100 μm. (E) Representative Western blot analyses of TNFα and NFκB1 and their quantifications. n = 3. The bars represent the mean ± SD; N.S. means no significant; *P < 0.05; **P < 0.01; ***P < 0.001.