Table 1 Patients characteristics stratified by PD-L1 expression levels
Variables | All cases (N = 4550) | PD-L1 TPS | P values | ||
|---|---|---|---|---|---|
PD-L1 < 1% (N = 3017) | 1 ≤ PD-L1 ≤ 49% (N = 1013) | PD-L1 ≥ 50% (N = 520) | |||
Age (years) |  |  |  |  | P < 0.001 |
 Median (IQR) | 62 (55, 68) | 62 (54, 67) | 62 (55, 68) | 64 (58, 69) |  |
Mean (SD) | 61.1 (9.4) | 60.7 (9.6) | 61.2 (9.3) | 62.9 (8.5) | Â |
 Range | (17, 85) | (17, 85) | (20, 84) | (34, 83) |  |
Sex |  |  |  |  | P < 0.001 |
 Female | 2204 | 1679 (76.2) | 404 (18.3) | 121 (5.5) |  |
 Male | 2346 51 | 1338 (57.0) | 609 (26.0) | 399 (17.0) |  |
Smoking history |  |  |  |  | P < 0.001 |
 Yes | 1815 | 975 (53.7) | 499 (27.5) | 341 (18.8) |  |
 No | 2735 | 2042 (74.7) | 514 (18.8) | 179 (6.5) |  |
Histology |  |  |  |  | P < 0.001 |
 AIS/MIA | 156 | 151 (96.8) | 5 (3.2) | 0 (0) |  |
 IAC | 3660 | 2619 (71.6) | 744 (20.3) | 297 (8.1) |  |
 SQCC | 642 | 213 (33.2) | 229 (35.7) | 200 (31.2) |  |
 LCC | 49 | 27 (55.1) | 13 (26.5) | 9 (18.4) |  |
 ASC | 25 | 1 (4.0) | 15 (60.0) | 9 (36.0) |  |
 Others | 18 | 6 (33.3) | 7 (38.9) | 5 (27.8) |  |
T stage |  |  |  |  | P < 0.001 |
 T0/1 | 3022 | 2262 (74.9) | 555 (18.4) | 205 (6.8) |  |
 T2 | 936 | 443 (47.3) | 303 (32.4) | 190 (20.3) |  |
 T3 | 303 | 155 (51.2) | 79 (26.1) | 69 (22.8) |  |
 T4 | 224 | 126 (56.3) | 62 (27.7) | 36 (16.1) |  |
 Tx | 65 | 31 (47.7) | 14 (21.5) | 20 (30.8) |  |
N stage |  |  |  |  | P < 0.001 |
 N0 | 3502 | 2558 (73.0) | 657 (18.8) | 287 (8.2) |  |
 N1 | 323 | 140 (43.3) | 113 (35.0) | 70 (21.7) |  |
 N2 | 679 | 298 (43.9) | 230 (33.9) | 151 (22.2) |  |
 N3 | 40 | 19 (47.5) | 10 (25.0) | 11 (27.5) |  |
 Nx | 6 | 2 (33.3) | 3 (50.0) | 1 (16.7) |  |
M stage |  |  |  |  | P < 0.001 |
 M0 | 4353 | 2915 (67.0) | 966 (22.2) | 472 (10.8) |  |
 M1 | 56 | 39 (69.6) | 9 (16.1) | 8 (14.3) |  |
 Mx | 141 | 63 (44.7) | 38 (27.0) | 40 (28.4) |  |
TNM stage |  |  |  |  | P < 0.001 |
 0/IA | 2633 | 2082 (79.1) | 423 (16.1) | 128 (4.9) |  |
 IB | 422 | 229 (54.3) | 121 (28.7) | 72 (17.1) |  |
 II | 524 | 247 (47.1) | 163 (31.1) | 114 (21.8) |  |
 III | 773 | 356 (46.1) | 259 (33.5) | 158 (20.4) |  |
 IV | 56 | 39 (69.6) | 9 (16.1) | 8 (14.3) |  |
 x | 142 | 64 (45.1) | 38 (26.8) | 40 (28.2) |  |
STAS |  |  |  |  | P < 0.001 |
 Absence | 1927 | 1555 (80.7) | 295 (15.3) | 77 (4.0) |  |
 Presence | 981 | 555 (56.6) | 301 (30.7) | 125 (12.7) |  |
 Unknown | 1642 | 907 (55.2) | 417 (25.4) | 318 (19.4) |  |