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Table 2 The top 25 smoke related DEGs identified in the ferret, mouse and human lungs shown in order of statistically significance for the ferret study

From: Comparative transcriptomics in human COPD reveals dysregulated genes uniquely expressed in ferrets

FERRET

log2FC

p-value

Padj

MOUSE

log2FC

p-value

padj

HUMAN

Wilcox p-value

Fold change

CD84

2.22

4.64E−56

3.81E−52

CD84

1.40

2.11E−13

1.01E−10

CD84

2.14E−09

1.40

CYP1B1

2.33

5.85E−48

2.41E−44

CYP1B1

0.89

9.33E−11

1.28E−08

CYP1B1

1.14E−19

4.53

ATP6V0D2

3.99

2.70E−29

3.42E−26

ATP6V0D2

1.04

1.11E−06

3.18E−05

ATP6V0D2

7.64E−16

5.89

PLD3

1.30

2.55E−28

2.62E−25

PLD3

1.23

8.27E−17

4.37E−13

PLD3

1.17E−07

1.32

CD180

1.63

1.44E−27

1.19E−24

CD180

0.39

4.42E−03

2.42E−02

CD180

1.66E−08

1.59

IGSF6

1.14

2.64E−25

1.89E−22

IGSF6

0.37

1.90E−03

1.24E−02

IGSF6

5.24E−14

1.96

TYROBP

1.57

3.37E−25

2.31E−22

TYROBP

0.77

3.38E−08

1.85E−06

TYROBP

7.77E−12

1.37

P2RX4

1.04

3.09E−24

1.89E−21

P2RX4

0.30

3.68E−05

5.37E−04

P2RX4

3.39E−10

1.36

INHBA

2.60

3.39E−24

1.99E−21

INHBA

1.02

8.99E−09

6.30E−07

INHBA

2.90E−10

1.66

MS4A7

1.25

5.20E−24

2.85E−21

MS4A7

1.59

4.51E−13

1.99E−10

MS4A7

2.74E−10

1.38

UCHL1

3.23

1.88E−22

9.68E−20

UCHL1

0.51

6.05E−07

1.94E−05

UCHL1

6.11E−11

2.08

NEK6

1.22

2.37E−22

1.18E−19

NEK6

0.71

5.95E−08

2.94E−06

NEK6

1.27E−16

2.05

CD68

1.75

4.96E−22

2.40E−19

CD68

1.75

4.27E−14

2.78E−11

CD68

7.47E−11

1.84

MSR1

2.07

1.95E−21

7.46E−19

MSR1

1.20

2.13E−04

2.20E−03

MSR1

4.05E−11

1.71

SLC15A3

1.27

7.11E−21

2.66E−18

SLC15A3

0.92

7.71E−13

2.81E−10

SLC15A3

2.20E−12

1.55

GRN

1.09

7.73E−21

2.83E−18

GRN

0.62

2.10E−12

5.69E−10

GRN

4.90E−10

1.39

CTSB

1.83

1.32E−20

4.64E−18

CTSB

0.61

1.22E−11

2.47E−09

CTSB

1.56E−11

1.55

SLC11A1

1.74

3.12E−20

9.88E−18

SLC11A1

1.13

2.93E−10

3.53E−08

SLC11A1

1.46E−10

1.79

CD53

1.13

3.25E−20

1.01E−17

CD53

0.58

1.50E−06

3.93E−05

CD53

2.08E−09

1.27

CTSS

1.24

4.99E−20

1.52E−17

CTSS

0.60

1.82E−07

7.35E−06

CTSS

2.24E−08

1.30

SLC7A11

3.39

2.09E−17

5.37E−15

SLC7A11

1.87

4.24E−12

1.09E−09

SLC7A11

1.13E−09

1.71

LITAF

1.25

3.89E−17

9.69E−15

LITAF

0.43

1.49E−05

2.61E−04

LITAF

7.65E−10

1.26

BLVRA

1.03

6.85E−16

1.45E−13

BLVRA

0.43

8.24E−08

3.82E−06

BLVRA

8.95E−08

1.26

CD86

1.11

9.72E−16

1.97E−13

CD86

1.18

1.57E−09

1.37E−07

CD86

6.29E−14

1.76

CTSZ

1.18

1.15E−15

2.30E−13

CTSZ

1.09

2.76E−14

2.08E−11

CTSZ

5.38E−08

1.32

  1. The statistical metrics reported for the mouse and human are computed from the mouse 24 week smoke exposed study [6] and the human smoking study [14] respectively. The log2FC is log2 fold change; the padj is adjusted p-value
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Respiratory Research

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