Fig. 4

A Venn diagram depicting overlap between differentially expressed genes (DEGs) in smoke-exposed ferret, human COPD, and smoke-exposed murine lungs. The number of DEGs in common between smoke-exposed ferrets, human COPD [14], and smoke-exposed mice [6] are shown. B Circos plot of smoking-related genes overlapping between smoke-exposed ferret, human COPD, and smoke-exposed murine lungs. The gene chromosomal positions are based on the human genome and shown inside the circles. The first pair of circles (light blue and dark blue) represents the dysregulated genes from the long term (24 weeks) smoke-exposed mouse [6]. The upregulated genes are plotted in the dark blue circle pointing outward whilst the downregulated genes are plotted in the light blue circle pointing inward. The second pair of circles (light red and dark red) show the ferret genes dysregulated due to smoke exposure. The upregulated genes are in the dark red circle and the downregulated genes are in the light red circle. The third pair of circles (light green and dark green) show the “human smoking” gene signature [6, 14]. The upregulated genes are in the dark green circle, whilst the downregulated genes are in the light green circle. The length of the line is proportional to the −log₁₀ FDR values for differential expression in human and for the −log₁₀ FDR values in murine and for the −log₁₀ p_adj for the ferret. Genes highlighted are statistically significant from the respective studies