Prophylactic cranial irradiation (PCI) versus active surveillance in patients with limited-stage small cell lung cancer: a retrospective, multicentre study

Table 2 Univariable and multivariable analyses of BM and OS

Characteristics	Univariable (BM)	Multivariable (BM)		Univariable (OS)	Multivariable (OS)
Characteristics	p value	HR (95% CI)	p value	p value	HR (95% CI)	p value
Age, y	0.881			0.013
< 65		1 (ref)			1 (ref)
≥ 65		1.01 (0.70–1.47)	0.95		1.13 (0.88–1.45)	0.349
Gender	0.099			0.001
Male		1 (ref)			1 (ref)	.
Female		0.79 (0.51–1.23)	0.29		0.80 (0.59–1.09)	0.156
ECOG PS	0.875			0.119
0		1 (ref)			1 (ref)
1		1.27 (0.82–1.95)	0.28		1.02 (0.74–1.42)	0.897
2		1.67 (0.66–4.18)	0.28		1.07 (0.58–1.96)	0.832
Smoking status	0.277			0.001
Never		1 (ref)			1 (ref)
Former		1.07 (0.59–1.95)	0.82		1.34 (0.90–2.00)	0.148
Current		0.91 (0.61–1.38)	0.66		1.26 (0.95–1.66)	0.108
Disease stage	0.004			0.017
I-II		1 (ref)			1 (ref)
III		1.59 (1.01–2.50)	0.047		1.04 (0.77–1.40)	0.798
CRT sequence	0.351			0.005
Sequential		1 (ref)			1 (ref)
Concurrent		0.79 (0.58–1.07)	0.13		0.66 (0.53–0.83)	< 0.001
Response to CRT	0.001			< 0.001
PR		1 (ref)			1 (ref)
CR		0.58 (0.40–0.84)	0.004		0.42 (0.32–0.54)	< 0.001
PCI	0.002			0.291
No		1 (ref)			1 (ref)
Yes		0.60 (0.45–0.80)	< 0.001		0.85 (0.69–1.04)	0.112

BM brain metastases, OS overall survival, HR hazard ratio, CI confidence interval, y years, ECOG PS Eastern Cooperative Oncology Group performance status, CRT chemoradiotherapy, CR complete response, PR partial response, PCI prophylactic cranial irradiation

ISSN: 1465-993X