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Fig. 7 | Respiratory Research

Fig. 7

From: Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis

Fig. 7

Schematic concept of the FGF10/FGFR1/ERK/SOX9/HS6ST1/HS loop in glycocalyx synthesis and lung repair. A model could be suggested in which cigarette smoke impairs endothelial glycocalyx and FGFR1 signaling, while FGF10 attenuates the development of emphysema and the shedding of glycocalyx induced by CSE in animal models. Mechanistically, FGF10 alleviates smoke-induced endothelial apoptosis and glycocalyx repair through a FGFR1/ERK/SOX9/HS6ST1 loop

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Respiratory Research

ISSN: 1465-993X

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