Fig. 7
From: Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC
A Effects of mosliciguat after inhaled application on systolic PAP during hypoxia-induced vasoconstriction in conscious dogs (n = 3). B Mean PAP decrease evoked by mosliciguat after inhaled application during hypoxia challenge in conscious dogs. PAP decrease for each animal is calculated as follows: PAP decrease = (SUM of mPAP from 10–40 min of mosliciguat-treated animal) ‒ (SUM of mPAP from 10–40 min of respective vehicle-treated animal)/number of time points. mPAP mean pulmonary arterial pressure, PAP mean pulmonary arterial pressure, SEM standard error of the mean, sPAP systolic pulmonary arterial pressure