Fig. 6

Treatment with DNA-PKcs specific inhibitor (NU7026) reversed pulmonary vascular remodeling but not pulmonary hypertension after HPH models established. A Establishment and treatment for rat HPH models. B NU7026 reversed pulmonary vascular remodeling after rat HPH models establishment. C, D NU7026 have no change on right ventricular systolic pressure (RVSP) and right ventricular hypertrophy index [RV/(LV + S)]. E NU7026 suppressed DNA-PKcs protein levels in rat HPH models. Bar 100 µm