Table 2 Clinical and Sleep Characteristics of OSA Subjects (n = 5748) according to APOC

Demographic and clinical characteristics

 Men, n (%)

2030 (82.35)

605 (77.46)

1213 (83.94)

212 (88.70)^###

2783 (84.77)*

 In man (%)

2030/4813 (42.18)

605 (12.57)

1213 (25.20)

212 (4.41)

2783 (57.82)***

 In women (%)

435/935 (46.52)

176 (12.82)

232 (24.81)

27 (2.89)

500 (53.48)**

 Age, yrs

44 (35–54)

43 (35–54)

45 (36–55)

42 (35–51)^#

43 (35–53)*

BMI, kg/m2

26.49 (24.56–28.73)

25.71 (23.72–27.71)

26.73 (24.86–29.05)

28.15 (26.18–30.46)^###

27.64 (25.17–30.07)***

NC, cm

40 (37.50–41.50)

38.50 (36–41)

40 (38–42)

41 (39–43)^###

40 (38–42.50)***

WC, cm

96 (90–101)

92 (88–98)

96 (91–102)

100 (96–107)^###

99 (93–105)***

HC, cm

101 (97–105)

99 (95–103)

101 (97–106)

104 (100–109)^###

103 (98–108)***

WHR

0.94 (0.90–0.98)

0.93 (0.89–0.97)

0.95 (0.91–0.98)

0.97 (0.93–1)^###

0.96 (0.92–0.99)***

SBP, mmHg

120 (119–132)

120 (119–125)

122 (120–134)

126 (120–138)^###

123 (120–136)***

DBP, mmHg

80 (76–85)

80 (79–81)

80 (75–85)

80 (76–88)^###

80 (78–89)***

Hypertension, n (%)

630 (25.56)

168 (21.51)

401 (27.75)

61 (25.52)^##

940 (28.63)**

Diabetes mellitus, n (%)

215 (8.72)

60 (7.68)

136 (9.41)

19 (7.95)

270 (8.22)

CVD, n (%)

176 (7.14)

47 (6.02)

118 (8.17)

11 (4.60)

275 (8.38)

MS, n (%)

444 (18.01)

111 (14.21)

260 (17.99)

73 (30.54)^###

573 (17.45)***

Hyperlipidemia, n (%)

441 (17.89)

107 (13.70)

262 (18.13)

72 (30.13)^###

559 (17.03)

Smoking, n (%)

547 (22.19)

170 (21.77)

304 (21.04)

73 (30.54)^##

608 (18.52)***

Alcohol consumption, n (%)

1113 (45.15)

348 (44.56)

668 (46.23)

97 (40.59)

1915 (58.33)***

Snoring score, point

6 (5–8)

6 (4–8)

6 (5–8)

8 (5–9)^###

7 (5–9)***

ESS, point

7 (3–12)

7 (3–11)

7 (2–12)

9 (4–13)^###

9 (4–14)***

EDS, n (%)

726 (29.45)

198 (25.35)

431 (29.83)

97 (40.59)^###

1363 (41.52)***

Biochemical indicators

Fasting glucose, mmol/L

5.25 (4.89–5.73)

5.16 (4.85–5.59)

5.27 (4.90–5.74)

5.43 (4.93–6.21)^###

5.37 (4.98–5.96)***

Glucose 120 min, mmol/L

8.25 (6.24–11.73)

8.09 (6.07–11.82)

8.35 (6.28–11.73)

7.19 (6.32–10.58)

7.97 (6.35–11.50)

Fasting insulin, µU/mL

10.90 (7.45–15.79)

9.63 (6.56–13.70)

11.11 (7.74–16.51)

13 (9.95–20.19)^###

12.85 (8.46–18.65)***

Insulin 120 min, µU/mL

67.86 (41.43–120.40)

63 (35.57–138.90)

66.79 (41.15–118.95)

81.46 (63.62–123.78)

71.01 (44.07–127.90)

HOMA-IR

2.38 (1.52–3.72)

2.13 (1.33–3.21)

2.45 (1.56–3.90)

3.03 (2.08–5.02)^###

2.93 (1.72–4.56)***

TC, mmol/L

4.72 (4.16–5.32)

4.64 (4.11–5.28)

4.76 (4.20–5.36)

4.67 (4.08–5.29)^#

4.82 (4.22–5.47)***

TG, mmol/L

1.65 (1.15–2.33)

1.49 (1.06–2.08)

1.70 (1.19–2.42)

1.84 (1.27–2.55)^###

1.74 (1.23–2.54)***

HDL, mmol/L

1.02 (0.90–1.18)

1.06 (0.90–1.23)

1.02 (0.90–1.16)

0.98 (0.86–1.10)^###

1 (0.87–1.15)***

LDL, mmol/L

2.94 (2.44–3.47)

2.91 (2.40–3.40)

2.97 (2.48–3.50)

2.91 (2.43–3.52)

2.99 (2.47–3.53)*

ApoA-1, g/L

1.05 (0.94–1.18)

1.07 (0.95–1.19)

1.04 (0.94–1.18)

1.03 (0.93–1.15)^#

1.05 (0.95–1.18)

ApoB, g/L

0.84 (0.73–0.97)

0.82 (0.71–0.95)

0.85 (0.74–0.98)

0.81 (0.73–0.99)^##

0.87 (0.76–1)***

ApoE, mg/dL

4.28 (3.47–5.30)

4.09 (3.39–5.12)

4.32 (3.52–5.34)

4.49 (3.60–5.85)^###

4.41 (3.59–5.60)***

Lp (α), mg/dL

7.85 (3.90–16.30)

8.60 (4.16–18.74)

7.60 (3.90–15.10)

6.80 (3.48–15.75)^#

7.12 (3.80–14.90)*

ApoA/ApoB

1.26 (1.06–1.50)

1.30 (1.09–1.58)

1.25 (1.04–1.48)

1.23 (1.06–1.47)^###

1.21 (1.02–1.46)***

PSG

Mild OSA, n (%)

611 (24.79)

468 (59.92)

143 (9.90)

0 (0)^###

480 (14.62)***

Moderate OSA, n (%)

750 (30.43)

203 (25.99)

547 (37.85)

0 (0)^###

423 (12.89)***

Severe OSA, n (%)

816 (33.10)

90 (11.53)

648 (44.85)

78 (32.64)^###

855 (26.04)***

Extreme severe OSA, n (%)

288 (11.68)

20 (2.56)

107 (7.40)

161 (67.36)^###

1525 (46.45)***

AHI, events/h

27.30 (15–43.20)

12.20 (7.70–21.70)

30.70 (20.60–41.80)

61.10 (52.20–70.10)^###

52.10 (26–67.60)***

OAHI, events/h

12.03 (5.19–23.70)

4.95 (2.23–10.58)

14.35 (7.76–24.01)

34.51 (23.81–47.85)^###

27.27 (10.75–44.93)***

Longest time of obstructive respiratory event, second

46 (33.50–60)

36.50 (25.50–51)

49 (36–62)

57.50 (47–71.50)^###

57.50 (42.50–71.48)***

AHIREM, events/h

33 (13.20–52.30)

15.40 (5.60–33.60)

37.10 (20.20–53.10)

58.45 (46.18–70.80)^###

52.40 (30.90–65.10)***

AHINREM, events/h

26.25 (13.90–43.43)

12 (6.85–22.60)

30.10 (19.39–42.70)

59.65 (49.90–70.93)^###

51.55 (23.95–68.12)***

Supine AHI, events/h

41.20 (24.10–59.65)

20.90 (11.85–34.80)

46.30 (32.80–60.30)

71.30 (62.10–80.80)^###

43.70 (2–68.60)***

Non-supine AHI, events/h

9.70 (3.76–20.57)

2.30 (1.20–3.54)

13.42 (8.78–20.93)

36.36 (32.69–42.77)^###

49.59 (27.13–65.70)***

ODI, events/h

27.30 (14.80–43.60)

12.70 (7.70–22.80)

30.70 (20.80–43.40)

60.60 (48.70–72.65)^###

51.90 (25–69.50)***

Mean SaO2, %

95 (93–96)

96 (94–96)

95 (93–96)

93 (91–94)^###

93 (91–95)***

LSaO2, %

82 (74–86)

86 (81–89)

81 (74–85)

72 (64–78)^###

74 (64–82)***

CT90, % TST

3.09 (0.83–8.57)

0.90 (0.23–3.42)

3.87 (1.32–8.85)

13.49 (6.31–27.75)^###

10.72 (2.49–28.95)***

TST, min

413.20 (352.10–453.50)

410 (347.75–453)

415.30 (352.43–452.50)

417.50 (359–456.50)

426 (372.50–471.90)***

Supine Time, % TST

74.04 (47.91–84.90)

72.35 (49.76–83.66)

73.70 (44.92–85.16)

80.06 (58.61–87.20)^###

75.53 (36.01–85.79)**

Sleep efficiency, %

94.46 (86.73–98.68)

94.48 (86.52–98.86)

94.61 (87.09–98.63)

94.08 (84.56–98.43)

96.26 (89.53–99.39)***

N1, % TST

16.20 (8.50–25.20)

14.60 (7.30–23.55)

16.70 (8.80–26.30)

16.40 (9.10–26.80)^##

15.20 (6.90–25.70)*

N2, % TST

50.80 (37.50–59.40)

50.70 (38.60–59.05)

50.80 (37.10–59.55)

51.90 (35.40–60.20)

51.30 (38.10–61.70)**

SWS, % TST

12.40 (5.50–19.60)

13.20 (6.45–20.05)

11.90 (5.20–19.40)

10.40 (3.80–18.40)^#

10.80 (3.30–20.10)**

REM, % TST

10.30 (5.90–14.90)

10.80 (6.05–15.20)

10.20 (5.75–14.90)

9.80 (6–14.30)

9.80 (5.70–14.20)*

MAI, events/h

22.20 (12.70–35.30)

18.25 (11.13–28.28)

23.40 (13.50–36.05)

33.90 (18.80–52.80)^###

27.80 (15–50.20)***

Components of ArTH score

 AHI < 30 events/h, n (%)

1361 (55.21)

671 (85.92)

690 (47.75)

0 (0)

903 (27.51)

 LSaO2 > 82.5%, n (%)

1108 (44.95)

518 (66.33)

560 (38.75)

30 (12.55)

772 (23.52)

 Proportion of hypopneas > 58.3%, n (%)

760 (30.83)

313 (40.08)

408 (28.24)

39 (16.32)

640 (19.49)

 Absolute fraction of hypopnoeas, %

38.99 (16.67–63.95)

47.83 (21.90–73.61)

37.13 (16.04–61.51)

27.40 (8.82–49.44)

26.23 (7.66–50.75)

 ArTH Score, cmH2O

− 16.69 (− 22.29-[-11.97])

− 12.32 (− 16.74− [− 8.44])

− 17.85 (− 22.65− [− 13.37])

− 25.73 (− 30.98− [− 21.97])

− 24.15 (− 31.19− [− 16.50])

 Proportion with ArTH score ≥ 2, n (%)

1099 (44.58)

559 (71.57)

534 (36.96)

6 (2.51)

704 (21.44)

 In male, n (%)

845/2030 (41.63)

422/605 (69.75)

418/1213 (34.46)

5/212 (2.36)

521/2783 (18.72)

 In female, n (%)

254/435 (58.39)

137/176 (77.84)

116/232 (50)

1/27 (3.70)

183/500 (36.60)