Table 1 Conditions and mechanisms caused by deletion of Piezo1 ion channel
Deletion of Piezo | Disease | Description | Mechanism |
|---|---|---|---|
Global deletion | Died within 24Â h after birth | NA | NA |
Endothelial cells in embryo | Died at E9.5-E11.5 | NA | Impaired endothelial cell alignment in response to shear stress; failing to remodel arteries |
Endothelial cells in adult | Pulmonary edema | Increased pulmonary vascular hyperpermeability | Calpain in endothelial cleaved Src kinase to restore stability of the endothelial barrier |
PH | Pulmonary vascular remodeling | Failed to control the production of endothelial [Ca2+]i and NO | |
Smooth muscle cells | PH | Narrowed of the arterial diameter and thicken the arterial wall | Piezo1 has a trophic effect on resistance arteries, which could influence its diameter and wall thickness in hypertension |
Epithelial cells | NSCLC | Worsen prognosis of patients | Piezo regulate cell migration and tumor growth |
Myeloid cells | Lung inflammation | Caused Pseudomonas aeruginosa infection | Impaired expression of monocyte-dependent endothelin-1, stabilization of HIF1α |