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Fig. 1 | Respiratory Research

Fig. 1

From: Nintedanib modulates type III collagen turnover in viable precision-cut lung slices from bleomycin-treated rats and patients with pulmonary fibrosis

Fig. 1

Nintedanib reduced C3M concentrations in the PCLS supernatant from bleomycin in vivo treated rats. C3M concentrations from PCLS from bleomycin-treated rats incubated with nintedanib for 48 h compared with PCLS from vehicle-treated rats. Number of slices indicates the total number from all rats evaluated at that dose. Statistical differences between groups were analysed by Kruskal–Wallis test followed by Dunn’s multiple comparison test for nonparametric data. Data are shown as mean ± SEM. ***P < 0.001. C3M neo-epitope of MMP-9 mediated degradation of type III collagen, LLOD lower limit of detection, PCLS precision-cut lung slices, SEM standard error of the mean

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Respiratory Research

ISSN: 1465-993X

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