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Fig. 5 | Respiratory Research

Fig. 5

From: Platelet-derived growth factor (PDGF)-BB regulates the airway tone via activation of MAP2K, thromboxane, actin polymerisation and Ca2+-sensitisation

Fig. 5

(GPs’ PCLS): Activation of TP- and IP-receptors in PDGF-BB-induced bronchoconstriction. A Inhibition of TP-receptors by SQ29548 (◆) no pre-treatment/100 nM PDGF-BB (n = 5); (◇) pre-treatment with 10 µM SQ29548/100 nM PDGF-BB (n = 5). B Inhibition of IP-receptors by RO-1138 (◆) no pre-treatment/100 nM PDGF-BB (n = 8); (◇) pre-treatment with 1 µM RO-1138/100 nM PDGF-BB (n = 8). A/B Statistics was performed by a LMM. p < 0.05 are considered as significant: *p < 0.05, **p < 0.01 and ***p < 0.001

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Respiratory Research

ISSN: 1465-993X

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