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Fig. 6 | Respiratory Research

Fig. 6

From: Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice

Fig. 6

ODE-induced lung autoantigens, vimentin, serum inflammatory markers, and autoantibodies in the setting of CIA in DR4 mice. A Confocal images of lung tissue from treatment groups stained for citrulline (CIT)- and malondialdehyde-acetaldehyde (MAA)-modified proteins as well as vimentin. Bar graphs in B–D depict integrated density (+ SD) of B CIT- or C MAA-modified proteins, and D vimentin, quantified per each mouse. Bar graphs in E–G demonstrate serum levels of murine pentraxin-2 (E), serum levels of IgG antibody to MAA-modified proteins (F) utilizing human serum albumin, collagen type II, and vimentin as the substrate antigen, and BALF levels of IgG antibody to MAA (G), all quantified by ELISA. Statistical differences versus saline-treated control mice are designated by #p < 0.05, ##p < 0.01, ####p < 0.0001. Lines denote differences between groups (*p < 0.05, **p < 0.01, ****p < 0.0001). RU: relative units. Line scale is 100 μm

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Respiratory Research

ISSN: 1465-993X

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