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Fig. 2 | Respiratory Research

Fig. 2

From: Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice

Fig. 2

ODE-induced ectopic lymphoid aggregates and neutrophil infiltrates are increased in DR4 mice. A Representative H&E-stained lung section images from each treatment group with arrows indicating ectopic lymphoid aggregates. B Bar graph (mean + SD) demonstrating the number of aggregates enumerated in different treatment groups. C Confocal microscopy image of T cells (green), B cells (red), and nuclei (DAPI, blue) within ODE-induced ectopic lymphoid aggregates in WT and DR4 mice. D Confocal microscopy images of myeloperoxidase (MPO, red) staining of neutrophils and DAPI (blue) in lung parenchyma from designated treatment groups. E Bar graphs showing integrated density of MPO+ neutrophil staining. N = 5 mice/group. Statistical differences versus saline control group are indicated by ##p < 0.01, ###p < 0.001. Brackets between groups represents significant gene-ODE interaction (P-int). Line scale is 100 μm

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Respiratory Research

ISSN: 1465-993X

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