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Table 1 Characteristics of study participants

From: Blood gene expression risk profiles and interstitial lung abnormalities: COPDGene and ECLIPSE cohort studies

Characteristics

COPDGene training sample

COPDGene testing sample

ECLIPSE

p

n

734

735

571

 

Age in years (mean (SD))

65.08 (8.53)

64.91 (8.60)

64.04 (6.10)

0.054

Sex (No. (%) female)

341 (46.5)

371 (50.5)

195 (34.2)

 < 0.001

Race (No. (%) African American)

178 (24.3)

171 (23.3)

0 (0.0)

 < 0.001

Pack-years of smoking (mean (SD))

43.71 (23.86)

42.38 (21.85)

47.27 (26.45)

0.002

Current smoking status (No. (%))

253 (34.5)

250 (34.1)

129 (22.6)

 < 0.001

Outcomes

    

 ILA (No. (%)) *

122 (16.6)

126 (17.1)

37 (6.5)

 < 0.001

 Dead (No. (%))

84 (11.4)

73 (9.9)

107 (30.7)

 < 0.001

 Days followed (median [IQR])

1881.00 [1603.75, 2104.00]

1916.50 [1631.50, 2140.75]

2848.00 [1425.00, 2926.00]

 < 0.001

  1. ILA = interstitial lung abnormalities. *ILA prevalence in the overall population was 5.7% (586/10,364) in COPDGene and 1.3% (37/2,746) in ECLIPSE