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Table 2 Association of DHEAS in the lowest quartile with pulmonary function and survival in the derivation cohort (men with IPF)

From: Dehydroepiandrosterone in fibrotic interstitial lung disease: a translational study

DHEAS lowest quartile

Unadjusted

Adjusted for age

OR (95% CI)

p-value

OR (95% CI)

p-value

FVC, %

0.96 (0.90–1.01)

0.13

0.96 (0.90–1.01)

0.16

DLCO, %

0.84 (0.67–0.95)

0.03

0.82 (0.64–0.94)

0.03

CPI

1.12 (1.02–1.30)

0.05

1.15 (1.03–1.38)

0.04

 

HR (95% CI)

p-value

HR (95% CI)

p-value

Survivala

4.35 (1.44–13.1)

0.009

3.84 (1.25–11.7)

0.02

  1. E.g. every one % increase in FVC, %-predicted is associated with a 4% lower odds of a serum DHEAS value in the lowest quartile
  2. CI confidence interval, CPI composite physiologic index, DHEAS dehydroepiandrosterone sulfate, DLCO diffusing capacity of the lung for carbon monoxide, FVC forced vital capacity, HR hazard ratio, IPF idiopathic pulmonary fibrosis, OR odds ratio
  3. aTime to death or lung transplantation e.g. patients with DHEAS in the lowest quartile have a 4.35 higher hazard for early death or lung transplant compared to those with DHEAS values in the second to fourth quartile
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Respiratory Research

ISSN: 1465-993X

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