Fig. 6
From: Autophagy regulates the effects of ADSC-derived small extracellular vesicles on acute lung injury
The permeability of PMVECs was measured using a Transwell assay. LPS increased the permeability of endothelial cells, and this effect was significantly alleviated by ADSC-sEVs treatment. Autophagy inhibition weakened the protective effect of ADSC-sEVs against LPS-induced endothelial permeability. (the relative fluorescence at 6 h, control, 2407.67 ± 353.56 vs. LPS, 8251.00 ± 369.21 vs. LPS + ADSC-sEV, 4185.00 ± 396.32 vs. LPS + ADSCsiATG5-sEV, 6319.67 ± 421.00. the relative fluorescence at 12 h, control, 2260.33 ± 294.18 vs. LPS, 8190.00 ± 397.31, LPS + ADSC-sEV, 4251.00 ± 340.95 vs. LPS + ADSCsiATG5-sEV, 6228.33 ± 499.55). The experiment was repeated three times