Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle

Table 2 Gene Expression of Notable Corticosteroid Insensitive Genes

Gene symbol	Gene Name	FP		TNFα		FP + TNFα		IFNγ		FP + IFNγ		TNFα/IFNγ		FP + TNFα/IFNγ
Gene symbol	Gene Name	Log₂ Fold Change	FDR	Log₂ Fold Change	FDR	Log₂ Fold Change	FDR	Log₂ Fold Change	FDR	Log₂ Fold Change	FDR	Log₂ Fold Change	FDR	Log₂ Fold Change	FDR
CCL5	C–C motif chemokine ligand 5	− 1.01	0.5441	9.41	0.0003	4.0	0.0056	2.25	0.0484	0.54	0.5766	13.41	0.0000	11.86	0.0001
CCL8	C–C motif chemokine ligand 8	− 3.04	0.3309	2.97	0.0495	1.24	0.4297	6.40	0.0002	5.16	0.0006	11.68	0.0000	10.04	0.0000
CD38	CD38 molecule	0.32	0.835	5.37	0.0013	3.93	0.0100	5.91	0.0000	5.09	0.0002	10.92	0.0001	10.95	0.0001
CXCL10	C-X-C motif chemokine ligand 10	− 0.14	0.9090	6.63	0.0005	2.95	0.0243	5.74	0.0004	4.23	0.0126	13.69	0.0000	13.5	0.0000
CXCL11	C-X-C motif chemokine ligand 11	− 0.23	0.8111	5.61	0.0007	2.23	0.1134	5.79	0.0003	6.84	0.0000	13.33	0.0000	13.351	0.0000
CXCL9	C-X-C motif chemokine ligand 9	0.03	0.9683	2.10	0.0292	1.34	0.3096	5.34	0.0028	5.65	0.0011	13.77	0.0000	5.65	0.0000
IRF8	interferon regulatory factor 8	− 0.08	0.9876	1.63	0.3988	3.85	0.0466	6.05	0.0011	6.18	0.0007	10.77	0.0000	10.16	0.0001
ISG15	ISG15 ubiquitin like modifier	− 0.99	0.2039	3.94	0.0020	0.84	0.4926	3.64	0.0003	3.70	0.0025	5.69	0.0003	5.36	0.0011
Orai1	ORAI calcium release-activated calcium modulator 1	− 0.13	0.6608	0.97	0.0660	0.61	0.0508	0.14	0.5912	-0.14	0.6397	2.47	0.0004	1.92	0.0008
VCAM1	vascular cell adhesion molecule 1	−3.56	0.0015	6.31	0.0011	3.38	0.0374	2.56	0.0000	0.95	0.0114	8.22	0.0003	7.55	0.0006

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