Usage of compromised lung volume in monitoring steroid therapy on severe COVID-19

Respiratory Research

Table 5 Associations between steroid administration and changes in quantitative chest CT parameters (%) according to baseline parameters

Outcome	Coefficient	95% CI	P value
Changes in CL (%)
High CL group (≥ 23.90)	− 9.67	− 13.12 to − 6.22	< 0.01
Low CL group (< 23.90)	0.81	− 1.72 to 3.34	0.53
Changes in NNL (%)
High NNL group (≥ 18.02)	− 1.88	− 3.63 to − 0.12	0.04
Low NNL group (< 18.02)	− 0.17	− 1.20 to 0.86	0.75
Changes in PAL (%)
High PAL group (≥ 5.92)	− 6.74	− 9.29 to − 4.19	< 0.01
Low PAL group (< 5.92)	0.96	− 1.00 to 2.92	0.34
Changes in NAL (%)
High NAL group (≥ 59.23)	5.92	1.88 to 9.95	< 0.01
Low NAL group (< 59.23)	7.28	2.59 to 11.97	< 0.01
Changes in HI (%)
High HI group (≥ 7.62)	− 1.84	− 8.12 to 4.44	0.57
Low HI group (< 7.62)	− 0.35	− 3.73 to 3.02	0.84

Analyses using generalized estimating equations to implement linear regression models. Coefficients represent the differences in changes in quantitative CT parameters associated with steroid administration. All analyses were adjusted for duration. %CL, percentage of compromised lung volume, calculated as the sum of %PAL and %NNL; %NNL, percentage of nonaerated lung volume; %PAL, percentage of poorly aerated lung volume; %NAL, percentage of normally aerated lung volume; %HI, percentage of hyperinflated lung volume

ISSN: 1465-993X