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Fig. 8 | Respiratory Research

Fig. 8

From: Transcriptional inhibition of miR-486-3p by BCL6 upregulates Snail and induces epithelial–mesenchymal transition during radiation-induced pulmonary fibrosis

Fig. 8

Working model of EMT induction by IR-activated transcription factor BCL6 via miR-486-3p/Snail.BCL6 was activated and increased after IR, and binding to the promoter region of miR-486-3p inhibited the transcription of miR-486-3p, resulting in a decrease in pri-miR-486-3p content. pri-miR-486-3p reduction led to a decrease in miR-486-3p content and weakened the silencing effect of miR-486-3p on Snail. Thus, the above figure describes a complete Radiation-induced pulmonary fibrosis through the BCL6/miR-486-3p/Snail axis

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Respiratory Research

ISSN: 1465-993X

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