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Table 7 Clinical baseline characteristics, Changes of hemodynamics and NT-proBNP in the initial BPA session

From: Bilateral versus unilateral balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension

  First BPA sessions Unilateral BPA Bilateral BPA *p value
Clinical baseline characteristics (N) 92 54 38  
Age (years) 59 ± 12 60 ± 13 56 ± 11 0.10
Female (%) 63 (68%) 40 (74%) 23 (61%) 0.17
Heart rate 80.5 ± 13.2 79.0 ± 13.3 82.7 ± 12.8 0.20
Mean PAP (mmHg) 43.0 ± 13.6 41.9 ± 13.8 44.5 ± 13.3 0.37
PVR (Wood Unit) 8.9 (4.9, 15.1) 8.3 (5.1, 15.9) 9.9 (4.6, 14.1) 0.92
Cardiac output (L/min) 3.6 (2.7, 5.0) 3.4 (2.6, 5.5) 3.8 (3.3, 5.0) 0.18
Cardiac index (L/min/m2) 2.2 (1.7, 3.2) 2.1 (1.7, 3.2) 2.5 (2.1, 3.2) 0.22
NT-proBNP (pg/ml) 541.1 (120.0, 1823.8) 321.1 (120.0, 1816.0) 950.3 (110.4, 2092.3) 0.34
WHO functional class (I–II/III–IV) 56.5%/43.5% 57.4%/42.6% 55.3%/44.7% 0.84
Interval between BPA (days) 67 (35, 107) 64 (30, 94) 95 (63, 185) 0.02
Changes of hemodynamics (N) 62 39 23  
Heart rate − 5.3 ± 11.8 − 3.7 ± 10.9 − 7.9 ± 12.9 0.18
Mean RAP (mmHg) 0.0 (− 4.0, 3.0) 0.0 (− 4.0, 3.3) − 1.0 (− 3.5, 2.0) 0.54
Systolic PAP (mmHg) − 8.9 ± 14.7 − 7.3 ± 13.3 − 11.6 ± 16.8 0.28
Diastolic PAP (mmHg) − 2.9 ± 6.9 − 2.4 ± 7.4 − 3.8 ± 5.9 0.45
Mean PAP (mmHg) − 5.1 ± 8.2 − 4.1 ± 7.4 − 6.8 ± 9.3 0.22
Cardiac output (L/min) 0.0 (− 0.6, 0.9) 0.0 (− 0.8, 0.9) 0.0 (− 0.5, 0.9) 0.62
Cardiac index (L/min/m2) 0.0 (− 0.4, 0.5) 0.0 (− 0.5, 0.5) 0.1 (− 0.2, 0.5) 0.41
PVR (Wood Unit) − 1.8 (− 4.5, 0.8) − 1.8 (− 4.2, 0.7) − 1.5 (− 5.8, 0.9) 0.99
PASO2 (%) 1.1 ± 7.5 0.9 ± 6.6 1.5 ± 8.9 0.77
MVSO2 (%) 0.1 ± 4.4 0.4 ± 4.2 − 0.2 ± 4.9 0.62
Changes of NT-proBNP (pg/ml) − 131.3 (− 937.8, 2.5) − 109.3 (− 725.4, − 2.4) − 488.0 (− 1359.2, 19.5) 0.53
  1. Continuous variables are expressed as mean ± standard deviation or median and interquartile range according to variable distribution
  2. BPA balloon pulmonary angioplasty, RAP right atrium pressure, PAP pulmonary artery pressure, PVR pulmonary vascular resistance, PASO2 pulmonary arterial oxygen saturation, MVSO2 mixed venous oxygen saturation, NT-proBNP N-terminal pro-B-type natriuretic peptide, WHO World Health Organization
  3. *Comparison between bilateral BPA and unilateral BPA