| |
First BPA sessions
|
Unilateral BPA
|
Bilateral BPA
|
*p value
|
|---|
|
Clinical baseline characteristics (N)
|
92
|
54
|
38
| |
|
Age (years)
|
59 ± 12
|
60 ± 13
|
56 ± 11
|
0.10
|
|
Female (%)
|
63 (68%)
|
40 (74%)
|
23 (61%)
|
0.17
|
|
Heart rate
|
80.5 ± 13.2
|
79.0 ± 13.3
|
82.7 ± 12.8
|
0.20
|
|
Mean PAP (mmHg)
|
43.0 ± 13.6
|
41.9 ± 13.8
|
44.5 ± 13.3
|
0.37
|
|
PVR (Wood Unit)
|
8.9 (4.9, 15.1)
|
8.3 (5.1, 15.9)
|
9.9 (4.6, 14.1)
|
0.92
|
|
Cardiac output (L/min)
|
3.6 (2.7, 5.0)
|
3.4 (2.6, 5.5)
|
3.8 (3.3, 5.0)
|
0.18
|
|
Cardiac index (L/min/m2)
|
2.2 (1.7, 3.2)
|
2.1 (1.7, 3.2)
|
2.5 (2.1, 3.2)
|
0.22
|
|
NT-proBNP (pg/ml)
|
541.1 (120.0, 1823.8)
|
321.1 (120.0, 1816.0)
|
950.3 (110.4, 2092.3)
|
0.34
|
|
WHO functional class (I–II/III–IV)
|
56.5%/43.5%
|
57.4%/42.6%
|
55.3%/44.7%
|
0.84
|
|
Interval between BPA (days)
|
67 (35, 107)
|
64 (30, 94)
|
95 (63, 185)
|
0.02
|
|
Changes of hemodynamics (N)
|
62
|
39
|
23
| |
|
Heart rate
|
− 5.3 ± 11.8
|
− 3.7 ± 10.9
|
− 7.9 ± 12.9
|
0.18
|
|
Mean RAP (mmHg)
|
0.0 (− 4.0, 3.0)
|
0.0 (− 4.0, 3.3)
|
− 1.0 (− 3.5, 2.0)
|
0.54
|
|
Systolic PAP (mmHg)
|
− 8.9 ± 14.7
|
− 7.3 ± 13.3
|
− 11.6 ± 16.8
|
0.28
|
|
Diastolic PAP (mmHg)
|
− 2.9 ± 6.9
|
− 2.4 ± 7.4
|
− 3.8 ± 5.9
|
0.45
|
|
Mean PAP (mmHg)
|
− 5.1 ± 8.2
|
− 4.1 ± 7.4
|
− 6.8 ± 9.3
|
0.22
|
|
Cardiac output (L/min)
|
0.0 (− 0.6, 0.9)
|
0.0 (− 0.8, 0.9)
|
0.0 (− 0.5, 0.9)
|
0.62
|
|
Cardiac index (L/min/m2)
|
0.0 (− 0.4, 0.5)
|
0.0 (− 0.5, 0.5)
|
0.1 (− 0.2, 0.5)
|
0.41
|
|
PVR (Wood Unit)
|
− 1.8 (− 4.5, 0.8)
|
− 1.8 (− 4.2, 0.7)
|
− 1.5 (− 5.8, 0.9)
|
0.99
|
|
PASO2 (%)
|
1.1 ± 7.5
|
0.9 ± 6.6
|
1.5 ± 8.9
|
0.77
|
|
MVSO2 (%)
|
0.1 ± 4.4
|
0.4 ± 4.2
|
− 0.2 ± 4.9
|
0.62
|
|
Changes of NT-proBNP (pg/ml)
|
− 131.3 (− 937.8, 2.5)
|
− 109.3 (− 725.4, − 2.4)
|
− 488.0 (− 1359.2, 19.5)
|
0.53
|
- Continuous variables are expressed as mean ± standard deviation or median and interquartile range according to variable distribution
- BPA balloon pulmonary angioplasty, RAP right atrium pressure, PAP pulmonary artery pressure, PVR pulmonary vascular resistance, PASO2 pulmonary arterial oxygen saturation, MVSO2 mixed venous oxygen saturation, NT-proBNP N-terminal pro-B-type natriuretic peptide, WHO World Health Organization
- *Comparison between bilateral BPA and unilateral BPA
