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Fig. 8 | Respiratory Research

Fig. 8

From: C/EBP homologous protein promotes Sonic Hedgehog secretion from type II alveolar epithelial cells and activates Hedgehog signaling pathway of fibroblast in pulmonary fibrosis

Fig. 8

Schematic model of the CHOP induced Shh secretion by AECII and activation of fibroblast during IPF. Multiple factors contribute to ER stress of AECII during IPF. The UPR induced by ER stress upregulates CHOP. Then, CHOP regulates the expression and secretion in an undefined mechanism. Secreted Shh activates HH signaling of fibroblast and promotes ECM synthesis, thus accelerates the development of pulmonary fibrosis

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Respiratory Research

ISSN: 1465-993X

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