Skip to main content
Fig. 2 | Respiratory Research

Fig. 2

From: C/EBP homologous protein promotes Sonic Hedgehog secretion from type II alveolar epithelial cells and activates Hedgehog signaling pathway of fibroblast in pulmonary fibrosis

Fig. 2

IPF lungs show extensive HH signaling activation. A Representative immunofluorescence and HE images on paraffin section by dual staining for Shh (green) and CHOP (red) of normal (n = 6) and IPF (n = 6) lung tissue. Arrows indicate AECII expressing CHOP and Shh. Bar = 20 μm. B Detecting the GLI1 and GLI2 expression patterns in IPF lungs show prominent expression of both GLI1 and GLI2 in lung mesenchyme. α-SMA (red) positive cells indicate smooth muscle outline airways and vessels, as well as myofibroblasts. Solid lines, airways. Dotted lines, blood vessels. SM, smooth muscles. Bar = 50 μm

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us