Exploring genetic association of insomnia with allergic disease and asthma: a bidirectional Mendelian randomization study

Table 1 Pleiotropy and heterogeneity test of insomnia on allergic disease, asthma and its phenotypes

Outcomes	MR-Egger Test			Cochrane Q Test								MR-PRESSO Global Test
	MR-Egger Test			MR-Egger				IVW				MR-PRESSO Global Test
	Intercept	SE	P-value	Q	Q_df	I²	P-value	Q	Q_df	I²	P-value	RSSobs	P-value
Allergic disease	0.002	0.002	0.360	218.5	194	0.112	0.110	219.0	195	0.110	0.110	221.750	0.104
Asthma	0.004	0.003	0.135	130.7	111	0.151	0.098	133.3	112	0.160	0.083	136.229	0.071
Moderate-severe asthma	− 0.018	0.009	0.038	182.6	174	0.047	0.312	187.2	175	0.065	0.250	189.379	0.250
Adult-onset asthma	0.007	0.004	0.062	140.9	118	0.163	0.074	145.1	119	0.180	0.052	148.374	0.053
Childhood asthma	0.002	0.006	0.747	129.9	114	0.123	0.146	130.0	115	0.116	0.160	132.260	0.161

ISSN: 1465-993X